Promethazine Signals and signs and symptoms of overdosage with promethazine HCI vary from delicate melancholy on the central anxious method and cardiovascular program to profound hypotension, respiratory despair, unconsciousness, and unexpected death.
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Ambulatory people need to be explained to to stop participating in this sort of routines until finally it is known that they do not grow to be drowsy or dizzy from promethazine and phenylephrine therapy. Small children really should be supervised to prevent probable harm in bike riding or in other dangerous things to do.
Notice must be given to the reestablishment of sufficient respiratory Trade by provision of the patent airway and establishment of assisted or controlled ventilation. Diazepam can be made use of to manage convulsions. Acidosis and electrolyte losses should be corrected. Observe that any depressant outcomes of promethazine will not be reversed by naloxone. Avoid analeptics which can bring about convulsions.
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Phenylephrine: A review in rabbits indicated that ongoing average overexposure to phenylephrine (three mg/working day) throughout the second fifty percent of pregnancy (22nd working day of gestation to shipping) may perhaps lead to perinatal wastage, prematurity, premature labor, And maybe fetal anomalies; when phenylephrine (three mg/day) was supplied to rabbits throughout the first fifty percent of pregnancy (third day following mating for 7 days), an important selection gave birth to litters of minimal beginning pounds.
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Promethazine must be applied cautiously in folks with heart problems or impairment of liver functionality.
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Due to dangers of addiction, abuse, and misuse with opioids, even at advised doses [see Warnings and Safeguards (five.one)], reserve promethazine HCl and codeine phosphate oral Option to be used in adult people for whom some great benefits of cough suppression are predicted to outweigh the threats, As well as in whom an suitable evaluation of your etiology of the cough continues to be produced.
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